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Image credit: Bernd Scheumann. “The clinical significance of this work is that it may encourage studies to evaluate whether simple increases in water intake may effectively mitigate obesity and metabolic syndrome,” said Dr. Miguel Lanaspa, a researcher in the Division of Renal Diseases and Hypertension at the University of Colorado Denver. Dr. Lanaspa and his colleagues wanted to understand why vasopressin, which maintains the body’s water levels, was elevated in those with obesity and diabetes. They fed mice sugar water, specifically fructose, and found that it stimulated the brain to make vasopressin. The vasopressin in turn stored the water as fat causing dehydration which triggered obesity. Treating the rodents with non-sugary water reduced the obesity. “We found that it does this by working through a particular vasopressin receptor known as V1b ,” Dr. Lanaspa said. “This receptor has been known for a while but no one has really understood its function.” “We found that mice lacking V1b were completely protected from the effects of sugar.” “We also show that the administration of water can suppress vasopressin and both prevent and treat obesity.” The scientists also discovered that dehydration can stimulate the formation of fat. “This explains why vasopressin is so high in desert mammals as they do not have easy access to water. So vasopressin conserves water by storing it as fat,” said Dr. Richard Johnson, also from the Division of Renal Diseases and Hypertension at the University of Colorado Denver. The new data fit with observations showing that obese people often have signs of dehydration, and explain why high salt diets may also cause obesity and diabetes. The team found that water therapy in mice effectively protected against metabolic syndrome. “The best way to block vasopressin is to drink water,” Dr. Lanaspa said. “This is hopeful because it means we may have a cheap, easy way of improving our lives and treating metabolic syndrome.” “Sugar drives metabolic syndrome in part by the activation of vasopressin. Vasopressin drives fat production likely as a mechanism for storing metabolic water.” “The potential roles of hydration and salt reduction in the treatment of obesity and metabolic syndrome should be considered.” Ana Andres-Hernando et al.

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Detroit automakers are struggling to keep production and shipments of highly profitable pickup trucks going as interruptions in manufacturing across the world have led to a global semiconductor chip shortage that's hitting the automotive industry. Ford Motor on Monday said it is cutting a shift at its Kentucky Truck Plant in Louisville that produces its larger F-Series pickups and full-size SUVs. It's also temporarily shuttering a plant in Ohio that builds vans and other trucks. Both plants are expected to return to normal production in a week, according to the company. The cuts come after Ford joined General Motors on Thursday in confirming it is partially assembling some trucks to be stored until parts become available. Stellantis , formerly Fiat Chrysler, also recently confirmed it was partially assembling some of its older Ram pickups due to a lack of semiconductor chips. "We are working closely with suppliers to address potential production constraints tied to the global semiconductor shortage and working to prioritize key vehicle lines for production, making the most of our semiconductor allocation," Ford spokeswoman Kelli Felker said in an emailed statement. For months, automakers have been prioritizing assembly of high-margin vehicles such as pickups by cutting production of cars and crossovers. The most recent actions show the difficulties facing the companies as they attempt to maintain production of those vehicles. Thus far, GM and Stellantis have been successful in keeping truck production her explanation up and running more than Ford, which previously cut shifts of its F-150 pickup. Semiconductor chips are extremely important components of new vehicles for infotainment systems, power steering and brakes, among other systems. The parts can contain several sizes and different types of chips. Consulting firm AlixPartners forecasts the shortage will cut $60.6 billion in revenue from the global automotive industry this year. GM expects the problem will reduce its free cash flow by $1.5 billion to $2 billion this year. Ford said the situation could lower its earnings by $1 billion to $2.5 billion in 2021. Automotive executives have characterized the situation as fluid.
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